The story follows two migrant workers, George Milton and Lennie Small, who travel together in search of job opportunities during the Great Depression.

George is intelligent and practical, while Lennie is physically strong but mentally disabled. Despite their differences, they share a deep friendship and depend on each other for companionship and survival. George acts as a protector and caretaker for Lennie, who often gets into trouble due to his childlike innocence and immense strength.

The duo dreams of owning their own piece of land, where they can live off the fat of the land and be free from the hardships of migrant life. This dream provides them with hope and a sense of purpose amid their difficult circumstances.

Their journey takes them to a ranch where they find temporary work. They encounter various characters, including Candy, an old ranch hand with a disabled hand, Curley, the boss's aggressive son, and Curley's lonely wife, who is trapped in a loveless marriage.

Tragedy strikes when Lennie unintentionally kills Curley's wife while trying to calm her down during a confrontation. George is faced with a difficult decision: to protect Lennie from the inevitable consequences of his actions or to allow him to face punishment. In a heart-wrenching act of mercy, George chooses to spare Lennie from a violent mob and shoots him himself, ending both their dreams and their companionship.

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