The novel follows a group of privileged teenagers over a five-day period leading up to New Year's Eve in 1999. The central character is 17-year-old White Mike, a drug dealer who has taken a year off from high school to sell marijuana to his affluent peers. On December 27th, White Mike's cousin Charlie gets involved with a dangerous new drug called "Twelve" and attempts to rob the dealer Lionel, resulting in Charlie's death. This sets off a chain of events involving White Mike's friend Hunter getting arrested for the murders, as well as other teenagers like Sara, Jessica, Chris, and Tobias getting caught up in the Twelve drug craze at various parties.

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