The play opens in 1823 Vienna, where Salieri, now an old man, addresses the audience as his confessors. He recounts his life story, beginning in 1781 when he was a respected composer in the court of Emperor Joseph II. Upon meeting the young Mozart, Salieri is awestruck by his prodigious talent and believes Mozart's music is the voice of God. Consumed by jealousy, Salieri vows to destroy Mozart's career and life.

Over the course of the play, Salieri schemes to undermine Mozart's success, spreading malicious rumors and manipulating the court against him. Despite his efforts, Mozart's genius continues to shine, driving Salieri deeper into madness and despair. The play culminates with Salieri confessing to poisoning Mozart, though it is left ambiguous whether he actually committed the murder.

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