The novel follows the story of Dwight Wilmerding, a 28-year-old man living in New York City who is struggling with a quarter-life crisis. Dwight works a monotonous job at Pfizer, lives with roommates, and is paralyzed by chronic indecisiveness, especially concerning his romantic life and career.

The plot takes a turn when Dwight loses his job and decides to take an experimental drug designed to cure indecision. With newfound determination, he sets off on a journey to Ecuador to visit Natasha, a former high school classmate with whom he has reconnected. Along the way, Dwight grapples with his internal conflicts, the implications of his decisions, and the broader political and social issues he encounters.

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